Premium
Oxidative transformations of 4‐methylcoumarins using dimethyldioxirane
Author(s) -
Ćavar Sanja,
Kovač Franci
Publication year - 2012
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.826
Subject(s) - dimethyldioxirane , chemistry , regioselectivity , double bond , molecule , organic chemistry , epoxide , oxidative phosphorylation , medicinal chemistry , catalysis , biochemistry
Efficient regioselective oxidation of the double CC bond of 4‐methylcoumarins with isolated dimethyldioxirane was performed, and related hydroxy and epoxy derivatives were obtained in good yields. All of obtained epoxides and most of hydroxy derivatives are novel compounds. The position of different electron‐donating groups attached at the aromatic part of molecule shows significant influence on kinetics and course of the reaction. J. Heterocyclic Chem., (2011).