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Tetrahydropyridinium bromide: Useful synthon to functionalized pyrrolidines
Author(s) -
Guideri Luca,
Noschese Rossella,
Ponticelli Fabio
Publication year - 2012
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.823
Subject(s) - synthon , chemistry , bromide , combinatorial chemistry , organic chemistry
1‐benzyl‐5‐(ethoxycarbonyl)‐2,3,4,5‐tetrahydropyridinium bromide undergoes ring contraction with a series of nucleophiles, getting 2,2‐disubstitued pyrrolidines. Moreover, from some of the new 2,2‐disubstitued pyrrolidines were synthesized spiro‐pyrrolidines. J. Heterocyclic Chem.,(2011).