A Simple, Convenient, and Efficient Synthetic Route for The Preparation of ( Z )‐3,5‐Dichloro‐ N ‐(3‐(4‐substitutedphenyl)‐4‐phenylthiazole‐2(3 H )‐ylide)benzamide Heterocyclic Compounds from Aroyl Thiourea Derivatives via  S ‐cyclization Mechanism | Zendy

Saeed Sohail | Zendy; Wong WingTak | Zendy

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A Simple, Convenient, and Efficient Synthetic Route for The Preparation of ( Z )‐3,5‐Dichloro‐ N ‐(3‐(4‐substitutedphenyl)‐4‐phenylthiazole‐2(3 H )‐ylide)benzamide Heterocyclic Compounds from Aroyl Thiourea Derivatives via S ‐cyclization Mechanism

Author(s) -

Saeed Sohail,

Wong WingTak

Publication year - 2012

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.820

Subject(s) - chemistry , benzamide , acetophenone , bromine , thiazole , ylide , elemental analysis , base (topology) , carbon 13 nmr , catalysis , medicinal chemistry , halogen , proton nmr , combinatorial chemistry , stereochemistry , organic chemistry , mathematical analysis , mathematics , alkyl

A series of variously substituted 1,3‐thiazole heterocyclic compounds ( 3a – 3d ) were prepared by base‐catalyzed S ‐cyclization of corresponding 2,4‐dichloro‐ N ‐{[(4‐substitutedphenyl)amino]carbonothioyl}benzamide ( 2a – 2d ) with acetophenone in the presence of bromine. The structure of all compounds was established by IR, 1 H‐NMR, 13 C‐NMR, elemental analysis, and X‐ray crystallographic analysis.

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