Synthesis and Antimicrobial Studies of Selenadiazolo Benzimidazoles

An efficient and eco‐friendly method has been developed for the synthesis of selenadiazolo benzimidazoles by the condensation of N ‐benzylbenzo[c][1,2,5]selenadiazole‐4,5‐diamine with various aromatic aldehydes catalyzed by xanthan sulfuric acid. All the synthesized compounds 5a , 5b , 5c , 5d , 5e , 5f , 5g , 5h , 5i , 5j were evaluated for in vitro antibacterial activity against Gram‐positive bacterial strains ( Bacillus subtilis , Staphylococcus aureus , and Streptococcus pyogenes ), and Gram‐negative bacterial strains ( Escherichia coli , Klebsiella pneumonia , and Salmonella typhimurium ) and antifungal against Aspergillus niger, Candida albicans , and Aspergillus flavus (Fungi). Compound 5i emerged as the most interesting compound in this series exhibiting excellent antimicrobial activity .