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Synthesis and Antimicrobial Studies of Selenadiazolo Benzimidazoles
Author(s) -
Kuarm B. Suresh,
Madhav J. Venu,
Rajitha B.
Publication year - 2013
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.817
Subject(s) - chemistry , antimicrobial , aspergillus flavus , bacillus subtilis , candida albicans , aspergillus niger , klebsiella pneumonia , microbiology and biotechnology , escherichia coli , staphylococcus aureus , salmonella typhi , enterobacter aerogenes , bacteria , organic chemistry , biochemistry , food science , biology , gene , genetics
An efficient and eco‐friendly method has been developed for the synthesis of selenadiazolo benzimidazoles by the condensation of N ‐benzylbenzo[c][1,2,5]selenadiazole‐4,5‐diamine with various aromatic aldehydes catalyzed by xanthan sulfuric acid. All the synthesized compounds 5a , 5b , 5c , 5d , 5e , 5f , 5g , 5h , 5i , 5j were evaluated for in vitro antibacterial activity against Gram‐positive bacterial strains ( Bacillus subtilis , Staphylococcus aureus , and Streptococcus pyogenes ), and Gram‐negative bacterial strains ( Escherichia coli , Klebsiella pneumonia , and Salmonella typhimurium ) and antifungal against Aspergillus niger, Candida albicans , and Aspergillus flavus (Fungi). Compound 5i emerged as the most interesting compound in this series exhibiting excellent antimicrobial activity .