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Synthesis and Biological Evaluation of Laxiflorin J Derivatives as Potential Antitumor Agents
Author(s) -
Liu JingPing,
Zhang HongBin,
Huang ShengXiong,
Pu JianXin,
Xiao WeiLie,
Zhang XuePing,
Xiao WenDing,
Lei Chun,
Sun HanDong
Publication year - 2012
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.816
Subject(s) - chemistry , in vitro , stereochemistry , inhibitory postsynaptic potential , cell culture , traditional medicine , pharmacology , combinatorial chemistry , biochemistry , medicine , genetics , biology
Laxiflorin J, isolated from the leaves of Isodon eriocalyx var. laxiflora , showed significant inhibitory activity toward T‐24 cells. A series of laxiflorin J derivatives were synthesized and their in vitro activity was evaluated against BEL‐7402, A‐549, HT‐29, HL‐60, MOLT‐4 tumor cell lines, with IC 50 values ranging from 1.3 to 42.2 μg mL −1 .
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