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Synthesis of 6‐Aminopropyl‐6H‐indolo[2,3‐b]quinoxaline Derivatives
Author(s) -
Shibinskaya Marina O.,
Kutuzova Nina A.,
Mazepa Alexandr V.,
Lyakhov Sergey A.,
Andronati Sergey A.,
Zubritsky Mykhayl Ju.,
Galat Valerij F.,
Lipkowski Janusz,
Kravtsov Victor Ch.
Publication year - 2012
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.805
Subject(s) - chemistry , quinoxaline , acetic acid , boiling , acetone , toluene , iodide , sodium iodide , ethyl iodide , methyl iodide , organic chemistry , medicinal chemistry
A series of 6‐(3‐aminopropyl)‐6H‐indolo[2,3‐b]quinoxalines were synthesized with high yields by the reaction of 6‐(3‐chloropropyl)‐6H‐indolo[2,3‐b]quinoxaline and corresponding amines in presence of tetrabutylammonium iodide in boiling toluene or dimethylformamide at room temperature. It was found that boiling of 6‐(3‐chloropropyl)‐6H‐indolo[2,3‐b]quinoxaline in acetone with sodium iodide or in acetic acid lead to intramolecular cyclization product.