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Synthesis of Some 3‐(4‐Aryl‐benzofuro[3,2‐ b ]pyridin‐2‐yl)coumarins and Their Antimicrobial Screening
Author(s) -
Patel Anil K.,
Patel Niraj H.,
Patel Mehul A.,
Brahmbhatt Dinker I.
Publication year - 2012
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.778
Subject(s) - chemistry , antimicrobial , aspergillus niger , pyridinium , acetic acid , bacteria , ammonium acetate , aryl , escherichia coli , coumarin , gram negative bacteria , antifungal , organic chemistry , medicinal chemistry , microbiology and biotechnology , biochemistry , high performance liquid chromatography , alkyl , gene , biology , genetics
The synthesis of some 3‐(4‐aryl‐benzofuro[3,2‐ b ]pyridin‐2‐yl)coumarins 3a–r has been carried out by the reaction of 3‐coumarinoyl methyl pyridinium salts 1a–c with 2‐arylidene aurones 2a–f in the presence of ammonium acetate and acetic acid under Kröhnke's reaction conditions. All the synthesized compounds were characterized by analytical and spectral data. They have been screened for their antibacterial activity against Escherichia coli (ATCC 25922) as Gram‐negative bacteria, Bacillus subtillis (ATCC 1633) as Gram‐positive bacteria and antifungal activity against Aspergillus niger (ATCC 9029) .