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Polycyclic N ‐Heterocyclic Compounds, Part 69: Synthesis of 5‐amino‐1,2‐dihydro[1]benzofuro[3,2‐ d ]furo[2,3‐ b ]pyridines and their transformations to related compounds
Author(s) -
Okuda Kensuke,
Takano Junichi,
Hirota Takashi,
Sasaki Kenji
Publication year - 2012
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.772
Subject(s) - chemistry , ring (chemistry) , benzofuran , pyridine , medicinal chemistry , potassium , derivative (finance) , stereochemistry , organic chemistry , financial economics , economics
Abstract Reaction of 3‐(3‐cyanopropoxy)[1]benzofuran‐2‐carbonitriles with potassium tert ‐butoxide gave 5‐amino‐1,2‐dihydro[1]benzofuro[3,2‐ d ]furo[2,3‐ b ]pyridines and 5‐amino‐2,3‐dihydro[1]benzofuro[3,2‐ b ]oxepin‐4‐carbonitriles as new ring systems. Reactions of the 5‐chloro derivative, obtained from 5‐amino‐1,2‐dihydro[1]benzofuro[3,2‐ d ]furo[2,3‐ b ]pyridine, produced a dihydrofuran ring‐opened compound and 5‐substituted compounds. J. Heterocyclic Chem.,(2011).