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Synthesis and conversion of 6‐fluoro derivatives of 1,3,4‐thiadiazolo‐[3,2‐ a ]pyrimidine
Author(s) -
Kukaniev Muhamadsho A.,
Párkányi Cyril
Publication year - 2011
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.767
Subject(s) - chemistry , pyrimidine , thiadiazoles , aryl , alkyl , medicinal chemistry , organic chemistry , combinatorial chemistry , stereochemistry
2‐Alkyl‐, 2‐aryl‐, and 2‐halo‐substituted derivatives of 7‐methyl‐6‐fluoro‐1,3,4‐thiadiazolo[3,2‐ a ]pyrimidin‐6‐one ( 3 ) were prepared by reaction of 2‐substituted 5‐amino‐1,3,4‐thiadiazoles ( 1 ) and ethyl 2‐fluoroacetoacetate ( 2 ) in polyphosphoric acid. A convenient procedure was developed for the synthesis of new 2‐amino derivatives of 2‐R‐7‐methyl‐6‐fluoro‐1,3,4‐thiadiazolo[3,2‐ a ]pyrimidin‐6‐one ( 5 ). J. Heterocyclic Chem., (2011).
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