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Synthesis of 10‐amino‐9‐aryl‐2,3,4,5,6,7,9,10‐octahydroacridine‐1,8‐dione derivatives
Author(s) -
Han GuangFan,
Cui Bin,
Chen LiZhuang,
Hu XiaoLei
Publication year - 2012
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.764
Subject(s) - chemistry , phenylhydrazine , hydrazine (antidepressant) , aryl , elemental analysis , proton nmr , catalysis , medicinal chemistry , organic chemistry , chromatography , alkyl
Abstract A series of novel 10‐amino‐9‐aryl‐2,3,4,5,6,7,9,10‐octahydroacridine‐1,8‐dione derivatives 4 were synthesized by hydrazine or phenylhydrazine and 9‐aryl‐1,8‐dioxo‐2,3,4,5,6,7,9‐heptahydroxanthene derivatives 3 , which were prepared by 5‐substituted‐1,3‐cyclohexanedione 1 and aromatic aldehydes 2 in the presence of concentrated H 2 SO 4 as a catalyst in water. The structures of all compounds were characterized by IR, MS, 1 H‐NMR, and elemental analysis, and the title compounds possess good fluorescence properties. J. Heterocyclic Chem., (2012).