Premium
Vilsmeier–Haack formylation of acetonitrile revisited: Synthesis of novel pyrazolo[1,5‐ a ]pyrimidines and triazolo[1,5‐ a ]pyrimidine
Author(s) -
Ghagare Maruti G.,
Birari Dilip R.,
Shelar Deepak P.,
Toche Raghunath B.,
Jachak Madhukar N.
Publication year - 2009
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.76
Subject(s) - formylation , chemistry , pyrimidine , acetonitrile , dimethylformamide , acetonitriles , organic chemistry , medicinal chemistry , combinatorial chemistry , stereochemistry , catalysis , solvent
Vilsmeier–Haack formylation of acetonitrile using dimethylformamide and phosphorus oxychloride leading to a novel intermediate, N ‐(( E )‐3‐(dimethylamino)‐2‐formylacryloyl)formamidine 2 and its utility in the synthesis of pyrimidine‐fused heterocycles such as pyrazolo[1,5‐ a ]pyrimidines and triazolo[1,5‐ a ]pyrimidine is reported. J. Heterocyclic Chem., 46 , 327 (2009).