Vilsmeier–Haack  formylation  of acetonitrile revisited: Synthesis of novel pyrazolo[1,5‐ a ]pyrimidines and triazolo[1,5‐ a ]pyrimidine | Zendy

Ghagare Maruti G. | Zendy; Birari Dilip R. | Zendy; Shelar Deepak P. | Zendy; Toche Raghunath B. | Zendy; Jachak Madhukar N. | Zendy

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Vilsmeier–Haack formylation of acetonitrile revisited: Synthesis of novel pyrazolo[1,5‐ a ]pyrimidines and triazolo[1,5‐ a ]pyrimidine

Author(s) -

Ghagare Maruti G.,

Birari Dilip R.,

Shelar Deepak P.,

Toche Raghunath B.,

Jachak Madhukar N.

Publication year - 2009

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.76

Subject(s) - formylation , chemistry , pyrimidine , acetonitrile , dimethylformamide , acetonitriles , organic chemistry , medicinal chemistry , combinatorial chemistry , stereochemistry , catalysis , solvent

Vilsmeier–Haack formylation of acetonitrile using dimethylformamide and phosphorus oxychloride leading to a novel intermediate, N ‐(( E )‐3‐(dimethylamino)‐2‐formylacryloyl)formamidine 2 and its utility in the synthesis of pyrimidine‐fused heterocycles such as pyrazolo[1,5‐ a ]pyrimidines and triazolo[1,5‐ a ]pyrimidine is reported. J. Heterocyclic Chem., 46 , 327 (2009).

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