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Improved synthesis of 2‐methoxyphenothiazine
Author(s) -
Ruan JianCheng,
Zhang Tao,
Wang Shuai,
Liu JinQiang,
Qian Chao,
Chen XinZhi
Publication year - 2012
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.750
Subject(s) - chemistry , yield (engineering) , aniline , resorcinol , condensation , catalysis , organic chemistry , solvent , combinatorial chemistry , thermodynamics , physics
A procedure for synthesis of 2‐methoxyphenothiazine ( 1 ) has been developed, starting from resorcinol and aniline by condensation , following methylation and cyclization . p ‐Toluenesulfonic acid and polysubstituted aromatics were employed as the catalyst of condensation and the solvent of cyclization , respectively, to improve the yield. The use of parallel experiments, statistical experimental design, and multivariate modeling made the total yield of the procedure as high as 74.2%. J. Heterocyclic Chem., (2012).