Improved synthesis of 2‐methoxyphenothiazine | Zendy

Ruan JianCheng | Zendy; Zhang Tao | Zendy; Wang Shuai | Zendy; Liu JinQiang | Zendy; Qian Chao | Zendy; Chen XinZhi | Zendy

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Improved synthesis of 2‐methoxyphenothiazine

Author(s) -

Ruan JianCheng,

Zhang Tao,

Wang Shuai,

Liu JinQiang,

Qian Chao,

Chen XinZhi

Publication year - 2012

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.750

Subject(s) - chemistry , yield (engineering) , aniline , resorcinol , condensation , catalysis , organic chemistry , solvent , combinatorial chemistry , thermodynamics , physics

A procedure for synthesis of 2‐methoxyphenothiazine ( 1 ) has been developed, starting from resorcinol and aniline by condensation , following methylation and cyclization . p ‐Toluenesulfonic acid and polysubstituted aromatics were employed as the catalyst of condensation and the solvent of cyclization , respectively, to improve the yield. The use of parallel experiments, statistical experimental design, and multivariate modeling made the total yield of the procedure as high as 74.2%. J. Heterocyclic Chem., (2012).

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