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Three component reactions of N‐nucleophiles and activated acetylenes with NH‐acids: A facile synthesis in water
Author(s) -
Charati Faramarz Rostami,
Hossaini Zinatossadat,
HosseiniTabatabaei Mohammad R.
Publication year - 2012
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.738
Subject(s) - chemistry , isoquinoline , nucleophile , component (thermodynamics) , catalysis , combinatorial chemistry , organic chemistry , physics , thermodynamics
A straightforward and efficient method for the synthesis of 1,2‐dihydroisoquinolines via a one‐pot, three‐component reaction of isoquinoline, activated acetylenes, and NH‐acids in water at 70°C without using any catalyst is reported. The method offers several advantages including high yields of products and an easy workup procedure. J. Heterocyclic Chem., (2012).