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Synthesis of Some New Heterocycles Derived from Ethyl 7‐Amino‐3‐(3‐methyl‐5‐oxo‐1‐phenyl‐2‐pyrazolin‐4‐yl)‐5‐aryl‐5 H ‐thiazolo[3,2‐ a ]pyrimidine‐6‐carboxylate of Biological Importance
Author(s) -
Youssef Mohamed Salah K.,
Abbady Mohamed S.,
Ahmed Ragaa A.,
Omar Ahmed A.
Publication year - 2013
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.735
Subject(s) - chemistry , ethyl cyanoacetate , reagent , pyrimidine , aryl , pyrazoline , medicinal chemistry , organic chemistry , stereochemistry , malononitrile , catalysis , alkyl
Ethyl 7‐amino‐3‐(3‐methyl‐5‐oxo‐1‐phenyl‐2‐pyrazolin‐4‐yl)‐5‐aryl‐5 H ‐thiazolo[3,2‐ a ]pyrimidine‐6‐carboxylate was synthesized by the reaction of 4‐(2‐aminothiazol‐4‐yl)‐3‐methyl‐5‐oxo‐1‐phenyl‐2‐pyrazoline with arylidene ethyl cyanoacetate and it transformed to related fused heterocyclic systems via reaction with various reagents. The biological activities of these compounds were evaluated.