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Synthesis of Some New Dihydropyrimidines by Iodine as a Catalyst at Ambient Temperature and Evaluation of Their Biological Activity
Author(s) -
Zalavadiya P. D.,
Ghetiya R. M.,
Dodiya B. L.,
Vekariya P. B.,
Joshi H. S.
Publication year - 2013
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.728
Subject(s) - chemistry , antimycobacterial , thiourea , catalysis , iodine , nuclear chemistry , antimicrobial , mycobacterium tuberculosis , biological activity , organic chemistry , combinatorial chemistry , tuberculosis , biochemistry , medicine , pathology , in vitro
An improved method for the synthesis of some new dihydropyrimidines from aromatic aldehydes, 1,3‐dicarbonyl compounds, and thiourea with significant enhancement in reaction rates, short reaction time (4–6 h), good to excellent yields (70–93%), and ambient temperature using molecular iodine as catalyst is described. The biological evaluation revealed that the newly synthesized compounds 4a , 4b , 4c , 4d , 4e , 4f , 4g , 4h , 4i , 4j and 7a , 7b , 7c , 7d , 7e , 7f , 7g , 7h , 7i , 7j exhibited good antimicrobial activity and moderate antimycobacterial activity against Mycobacterium tuberculosis H 37 RV.