Premium
One‐pot synthesis of 2,3‐disubstituted‐2,3‐dihydroquinazolin‐4( 1H )‐ones using [Hmim][NO 3 ]: An eco‐friendly protocol
Author(s) -
MohammadpoorBaltork Iraj,
Khosropour Ahmad Reza,
Moghadam Majid,
Tangestaninejad Shahram,
Mirkhani Valiollah,
Soltani Mohammad,
Mirjafari Arsalan
Publication year - 2011
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.721
Subject(s) - chemistry , ionic liquid , catalysis , condensation , environmentally friendly , organic chemistry , aryl , combinatorial chemistry , reaction conditions , condensation reaction , alkyl , ecology , biology , physics , thermodynamics
An efficient method for the synthesis of a series of 2,3‐disubstituted‐2,3‐dihydroquinazolin‐4( 1H )‐ones is described via one‐pot condensation reaction of isatoic anhydride, aryl aldehydes, and primary amines using a Brønsted acidic ionic liquid, [Hmim][NO 3 ], as a catalyst and medium. The present protocol enjoys convenient reaction and simple work‐up, greenness, short reaction times, and reusable catalyst as well as mild reaction conditions. J. Heterocyclic Chem., (2011).