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Synthesis and antimicrobial activities of new 4,6‐diaryl‐ 4,5‐dihydro‐3‐hydroxy‐ 2H ‐indazoles
Author(s) -
Amutha Parasuraman,
Nagarajan Samuthira
Publication year - 2012
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.720
Subject(s) - chemistry , aspergillus flavus , antimicrobial , aspergillus niger , candida albicans , staphylococcus aureus , escherichia coli , pseudomonas aeruginosa , rhizopus , proton nmr , carbon 13 nmr , antibacterial activity , salmonella , stereochemistry , organic chemistry , bacteria , microbiology and biotechnology , biochemistry , food science , fermentation , genetics , gene , biology
Abstract A series of new 4,6‐diaryl‐4,5‐dihydro‐3‐hydroxy‐2H‐indazoles 5a , 5b , 5c , 5d , 5e , 5f , 5g , 5h , 5i , 5j , 5k were synthesized by the cyclization of ethyl 2‐oxo‐4,6‐diarylcyclohex‐3‐ene carboxylates 4a , 4b , 4c , 4d , 4e , 4f , 4g , 4h , 4i , 4j , 4k . The compounds were characterized by IR, 1 H NMR, 13 C NMR, 2D NMR, and elemental analysis. The synthesized compounds were evaluated for in vitro antibacterial and antifungal activities against Staphylococcus aureus, Escherichia coli, Salmonella typhimurium, Pseudomonas aeruginosa, Candida albicans, Aspergillus niger, Aspergillus flavus , and Rhizopus sp. Most of the compounds exhibited good activity against the tested organisms. J. Heterocyclic Chem.,, (2012).