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An efficient synthesis of 2,3,4‐trisubstituted quinolines through alkynylation‐cyclization at ambient temperature
Author(s) -
Patil Dipti R.,
Salunkhe Sonali M.,
Deshmukh Madhukar B.,
Anbhule Prashant V.
Publication year - 2011
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.715
Subject(s) - chemistry , quinoline , zwitterion , alkynylation , pyridine , dimethyl acetylenedicarboxylate , organic chemistry , acetylenedicarboxylate , combinatorial chemistry , medicinal chemistry , catalysis , molecule , cycloaddition
A series of 2,3,4‐trisubstituted quinoline derivatives have been synthesized by reactions between 2‐aminoaryl ketones and dialkyl acetylenedicarboxylate. The synthetic pathway allows for the direct construction of said quinoline derivatives in pyridine/ethanol at ambient temperature through a zwitterion intermediate. J. Heterocyclic Chem., (2011)