Premium
An efficient synthesis of 5‐aryl‐4,5‐dihydro‐3‐(5‐methyl‐1‐ p ‐tolyl‐1 H ‐1,2,3‐triazol‐4‐yl)‐1‐(4‐phenylthiazol‐2‐yl)pyrazoles
Author(s) -
Dong WangJun,
Cui FuHong,
Gao ZhongLian,
Li RongShan,
Shen GuoLiang,
Dong HengShan
Publication year - 2011
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.706
Subject(s) - chemistry , aryl , medicinal chemistry , proton nmr , stereochemistry , organic chemistry , alkyl
Some new target products 5‐aryl‐4,5‐dihydro‐3‐(5‐methyl‐1‐ p ‐tolyl‐1 H ‐1,2,3‐triazol‐4‐yl)‐1‐(4‐phenylthiazol‐2‐yl)pyrazoles 5a , 5b , 5c , 5d , 5e , 5f , 5g , 5h , 5i , 5j have been synthesized by reaction of 2‐bromo‐1‐phenylethanone and compounds 4a , 4b , 4c , 4d , 4e , 4f , 4g , 4h , 4i , 4j which were prepared from the combination of thiosemicarbazide and ( E )‐3‐aryl‐1‐(5‐methyl‐1‐ p ‐tolyl‐1 H ‐1,2,3‐triazol‐4‐yl)‐prop‐2‐en‐1‐ones 3a , 3b , 3c , 3d , 3e , 3f , 3g , 3h , 3i , 3j . All the structures were established by MS, IR, CHN, and 1 H NMR spectra data. Synthesis of structure diversity is applied. J. Heterocyclic Chem., (2011).