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An efficient three‐component synthesis of hexahydroquinoline derivatives in ionic liquid
Author(s) -
Wang JuXian,
Shen GaoLing,
Shi DaQing
Publication year - 2011
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.703
Subject(s) - chemistry , aldehyde , ionic liquid , acetonitrile , component (thermodynamics) , catalysis , organic chemistry , combinatorial chemistry , physics , thermodynamics
A series of hexahydroquinoline derivatives were synthesized by the three‐component reaction of 5,5‐dimethyl‐3‐aminocyclohex‐2‐enone, aromatic aldehyde, and acyl acetonitrile in ionic liquid without using any catalyst. This protocol has the advantages of easier work‐up, milder reaction conditions, high yields, and environmentally benign procedure. J. Heterocyclic Chem., (2011).