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Synthesis, characterization, and in vitro biological studies of some novel pyran fused pyrimidone derivatives
Author(s) -
Mistry Prashant T.,
Kamdar Nimesh R.,
Haveliwala Dhaval D.,
Patel Saurabh K.
Publication year - 2012
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.700
Subject(s) - chemistry , pyran , formic acid , pyrazole , pyrimidine , acetic acid , carbon 13 nmr , antifungal , proton nmr , combinatorial chemistry , stereochemistry , in vitro , malononitrile , antibacterial activity , elemental analysis , organic chemistry , bacteria , catalysis , biochemistry , medicine , dermatology , biology , genetics
Abstract A variety of pyrano[2,3‐ d ]pyrimidine‐5‐one derivatives 5 , 5a , 5b , 5c , 5d , 5e , 5f , 5g , 5h , 5i , 5j , 6 , 6a , 6b , 6c , 6d , 6e , 6f , 6g , 6h , 6i , 6j have been synthesized from 6‐amino‐4‐(substituted phenyl)‐5‐cyano‐3‐methyl‐1‐phenyl‐1,4‐dihydropyrano[2,3‐ c ]pyrazole derivatives 4a , 4b , 4c , 4d , 4e , 4f , 4g , 4h , 4i , 4j via cyclization using formic acid and acetic acid. All the newly synthesized compounds have been characterized by IR, 1 H NMR, 13 C NMR, and elemental analysis. All the synthesized compounds have been screened for antibacterial, antifungal and antitubercular activity. J. Heterocyclic Chem., (2012).