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Synthesis of novel spiro(indolone‐3,2′‐[1,3,4]thiadiazol)‐2‐ones and evaluation of their antidepressant and anticonvulsant activities
Author(s) -
Hassan Alaa A.,
AbdelLatif Fathy F.,
ElDin Ahmed M. Nour,
AbdelAziz Mohamed,
Mostafa Sara M.,
Bräse Stefan
Publication year - 2011
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.687
Subject(s) - chemistry , anticonvulsant , piperidine , pentylenetetrazol , indoline , tail suspension test , ethanol , antidepressant , pharmacology , stereochemistry , medicinal chemistry , behavioural despair test , epilepsy , organic chemistry , psychiatry , psychology , medicine , anxiety
The reaction of 3‐(dicyanomethylene)‐2‐indolone in a solution of ethanol/piperidine with 4‐substituted thiosemicarbazides forms the derivatives of 5′‐(substituted amino)‐3′ H –spiro(indoline‐3,2′‐[1,3,4]thiadiazol‐2‐one. Rationales for these conversions involving the nucleophilic addition on the dicyanomethylene carbon atom are presented. The prepared compounds were evaluated each for antidepressant activity using tail suspension behavioral despair test and anticonvulsant activity against pentylenetetrazol induced seizures in mice. J. Heterocyclic Chem., (2011).