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Synthesis and antimicrobial activity of new C ‐furyl glycosides bearing substituted 1,3,4‐oxadiazoles
Author(s) -
ElSayed Wael A.,
Abbas HebatAllah S.,
Mohamed Ashraf M.,
AbdelRahman Adel A.H.
Publication year - 2011
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.679
Subject(s) - chemistry , antimicrobial , hydrazone , glycoside , acetic anhydride , organic chemistry , sugar , acetic acid , combinatorial chemistry , catalysis
New 2,5‐disubstituted 1,3,4‐oxadiazole derivatives bearing C ‐furyl glycoside moieties and their sugar hydrazone as well as their per‐ O ‐acetyl derivatives were synthesized starting from ethyl 2‐[5‐(3,4‐dihydroxytetrahydrofuran‐2‐yl)‐2‐methylfuran‐3‐yl]‐2‐oxoacetate. Heterocyclization of the sugar hydrazones using acetic anhydride afforded the corresponding oxadiazoline acyclic C ‐nucleosides. The antimicrobial activity evaluation showed that many of the synthesized compounds revealed moderate to high antimicrobial activity . J. Heterocyclic Chem., (2011)