Synthesis and  antimicrobial activity  of new  C ‐furyl glycosides bearing substituted 1,3,4‐oxadiazoles | Zendy

ElSayed Wael A. | Zendy; Abbas HebatAllah S. | Zendy; Mohamed Ashraf M. | Zendy; AbdelRahman Adel A.H. | Zendy

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Synthesis and antimicrobial activity of new C ‐furyl glycosides bearing substituted 1,3,4‐oxadiazoles

Author(s) -

ElSayed Wael A.,

Abbas HebatAllah S.,

Mohamed Ashraf M.,

AbdelRahman Adel A.H.

Publication year - 2011

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.679

Subject(s) - chemistry , antimicrobial , hydrazone , glycoside , acetic anhydride , organic chemistry , sugar , acetic acid , combinatorial chemistry , catalysis

New 2,5‐disubstituted 1,3,4‐oxadiazole derivatives bearing C ‐furyl glycoside moieties and their sugar hydrazone as well as their per‐ O ‐acetyl derivatives were synthesized starting from ethyl 2‐[5‐(3,4‐dihydroxytetrahydrofuran‐2‐yl)‐2‐methylfuran‐3‐yl]‐2‐oxoacetate. Heterocyclization of the sugar hydrazones using acetic anhydride afforded the corresponding oxadiazoline acyclic C ‐nucleosides. The antimicrobial activity evaluation showed that many of the synthesized compounds revealed moderate to high antimicrobial activity . J. Heterocyclic Chem., (2011)

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