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Synthesis and biological activities of a novel series of 3,6‐disubstituted‐1,2,4‐triazolo‐[3,4‐ b ]‐1,3,4‐thiadiazoles containing gem‐dimethylbenzyl moiety
Author(s) -
Puthiyapurayil Pushpan,
Poojary Boja,
Kumar Sunil,
Hunnur Raveendra
Publication year - 2011
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.674
Subject(s) - chemistry , moiety , thiadiazoles , antifungal , aryl , stereochemistry , proton nmr , antibacterial activity , carbon 13 nmr , combinatorial chemistry , medicinal chemistry , organic chemistry , bacteria , alkyl , medicine , dermatology , biology , genetics
A novel series of 3,6‐disubstituted‐1,2,4‐triazolo‐[3,4‐ b ]‐1,3,4‐thiadiazoles (6a–r) containing gem‐dimethyl benzyl moiety were prepared by the condensation of 4‐amino‐3‐aryl/aralkyl substituted‐5‐mercapto‐1,2,4‐triazoles ( 5a , 5b , 5c ) with various fluoro substituted aromatic acids in the presence of POCl 3 . IR, 1 H NMR, 13 C NMR, 2D NMR (COSY), and mass spectral data confirmed the structures of all the synthesized compounds. All the compounds were also screened for their antibacterial, antifungal and analgesic activities. Compounds 6b , 6d , 6f , 6g , 6h , 6i , 6m , 6n , 6o , 6p , and 6r exhibited promising antibacterial and compounds 6a , 6d , 6f , 6g , 6h , 6k , 6m , 6o , 6p , and 6q showed significant analgesic activities. J. Heterocyclic Chem., (2011)