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Clay‐supported 2‐phenyl‐1 H ‐imidazole derivatives for heterogeneous catalysis of Henry reaction
Author(s) -
Holešová Sylva,
Pařík Patrik,
Ludwig Miroslav
Publication year - 2011
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.669
Subject(s) - chemistry , imidazole , catalysis , yield (engineering) , thio , heterogeneous catalysis , nitroaldol reaction , homogeneous catalysis , homogeneous , medicinal chemistry , molar ratio , organic chemistry , polymer chemistry , materials science , physics , metallurgy , thermodynamics , enantioselective synthesis
Six derivatives ( 1 , 2 , 3 , 4 , 5 , 6 ) of 2‐phenyl‐1 H ‐imidazole were tested as catalysts of Henry reaction . Three new ( 4 , 5 , 6 ) 2‐phenyl‐1 H ‐imidazole derivatives, differently substituted (thio)ureas, were synthesized and determined by 1 H NMR and IR spectroscopy and elemental analysis. Two types of catalysis , homogeneous and heterogeneous, were examined and compared. Clay minerals Ca‐MMT and Cu‐MMT were used as solid supports for heterogeneous catalysis . The best results were obtained using compound 2 under conditions of heterogeneous method D from the point of view of yield and reaction time. J. Heterocyclic Chem., (2011)