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Improved synthesis of dihydrothiophenes derivatives under ultrasound irradiation
Author(s) -
Shi DaQing,
Zou Yi,
Hu Yu,
Wu Hui
Publication year - 2011
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.662
Subject(s) - malononitrile , chemistry , aldehyde , yield (engineering) , piperidine , component (thermodynamics) , combinatorial chemistry , multi component reaction , organic chemistry , thermodynamics , catalysis , physics
A series of dihydrothiphenes derivatives were synthesized via the four‐component reaction of aldehyde, malononitrile, 1,3‐thiazolidinedione, and piperidine at room temperature under ultrasound irradiation. Compared with the conventional methods, the remarkable advantages of this method are operational simplicity, higher yield, and shorter reaction time. J. Heterocyclic Chem., (2011).