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Synthesis and in vitro antibacterial assessment of novel chromones featuring 1,2,4‐oxadiazole
Author(s) -
Diwakar Santosh D.,
Joshi Ratnadeep S.,
Gill Charansing H.
Publication year - 2011
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.656
Subject(s) - chemistry , antibacterial activity , antimicrobial , in vitro , combinatorial chemistry , potency , gram , bacteria , oxadiazole , stereochemistry , organic chemistry , biochemistry , genetics , biology
In search for a new antibacterial agent with improved antimicrobial spectrum and potency, we designed and synthesized a series of novel 3‐(( Z )‐2‐(5‐methyl‐1,2,4‐oxadiazol‐3‐yl)‐2‐(4‐nitrophenyl)vinyl)‐4 H ‐chromen‐4‐ones 7a , 7b , 7c , 7d , 7e , 7f , 7g , 7h by convergent synthesis approach. All the synthesized compounds were assayed for their in vitro antibacterial activities against gram‐negative and gram‐positive bacteria. The preliminary structure‐activity relationship to elucidate the essential structure requirements for the antimicrobial activity has been described. J. Heterocyclic Chem., (2011).