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An efficient one‐pot synthesis of dispiropyrrolidine derivatives through 1,3‐dipolar cycloaddition reactions under ultrasound irradiation
Author(s) -
Liu Hai,
Zou Yi,
Hu Yu,
Shi DaQing
Publication year - 2011
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.654
Subject(s) - chemistry , isatin , cycloaddition , 1,3 dipolar cycloaddition , thiazolidine , sarcosine , ethanol , organic chemistry , combinatorial chemistry , medicinal chemistry , catalysis , glycine , biochemistry , amino acid
A series of dispiropyrrolidine derivatives were synthesized via the three‐component 1,3‐dipolar cycloaddition reaction of isatin, sarcosine and 5‐arylidene‐1,3‐thiazolidine‐2,4‐dione or 5‐arylidene‐4‐thioxo‐1,3‐thiazolidine‐2‐one in ethanol under ultrasound irradiation. This protocol has the advantages of mild reaction conditions, higher yields, and shorter reaction time. J. Heterocyclic Chem., (2011).