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Synthesis and antimicrobial activity of some 7‐aryl‐5,6‐dihydro‐14‐aza[1]benzopyrano[3,4‐ b ]phenanthren‐ 8H ‐ones
Author(s) -
Brahmbhatt Dinker I.,
Patel Niraj H.,
Patel Anil K.,
Patel Mehul A.,
Patel Varun G.
Publication year - 2011
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.648
Subject(s) - chemistry , ammonium acetate , bacillus subtilis , aryl , antimicrobial , acetic acid , candida albicans , proton nmr , antifungal , bacteria , escherichia coli , gram , organic chemistry , stereochemistry , microbiology and biotechnology , biochemistry , high performance liquid chromatography , alkyl , biology , gene , genetics
The title compounds, 7‐aryl‐5,6‐dihydro‐14‐aza[1]benzopyrano[3,4‐ b ]phenanthren‐ 8H ‐ones 3a , 3b , 3c , 3d , 3e , 3f , 3g , 3h , 3i , 3j , 3k , 3l have been synthesized by reacting various 4‐hydroxy coumarins 1a , 1b , 1c with 2‐arylidene‐1‐tetralones 2a , 2b , 2c , 2d in the presence of ammonium acetate and acetic acid under Krohnke's reaction condition. The structures of all the synthesized compounds were supported by analytical, IR, 1 H‐NMR, and 13 C‐NMR data. All the synthesized compounds 3a , 3b , 3c , 3d , 3e , 3f , 3g , 3h , 3i , 3j , 3k , 3l have been screened for their antibacterial activities against Escherichia coli (Gram −ve bacteria), Bacillus subtilis (Gram +ve bacteria), and antifungal activity against Candida albicans (Fungi). J. Heterocyclic Chem., (2011).