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Synthesis of novel piperidyl spirofused benzofurans/benzopyrans by radical cyclization
Author(s) -
Tang Zilong,
Mayrargue Joelle,
Alami Mouad
Publication year - 2011
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.630
Subject(s) - chemistry , benzopyrans , ring (chemistry) , radical cyclization , yield (engineering) , substituent , intramolecular force , benzene , medicinal chemistry , stereochemistry , organic chemistry , materials science , metallurgy
Several new piperidyl spirofused benzofurans and piperidyl spirofused benzopyrans were synthesized via an intramolecular radical cyclization as the key step. It was found that the yield of the formation of five‐member ring was much higher than that of six‐member ring. In addition , the substituent attached to the benzene ring had almost no effect on the cyclization . J. Heterocyclic Chem.,(2011).