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Behavior of 2‐iminothiazolidin‐4‐one with different reagents
Author(s) -
Hamama Wafaa S.,
Ismail Mohadamed A.,
Soliman Mamdoh,
Shaaban Saad,
Zoorob Hanafi H.
Publication year - 2011
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.628
Subject(s) - chemistry , formylation , electrophile , reagent , cycloaddition , benzene , organic chemistry , medicinal chemistry , combinatorial chemistry , catalysis
Annulations of 2‐imino‐4‐thiazolidinone ( 5 ) via cycloaddition followed by cyclocondensation reaction with 1,3‐diphenylpropenone ( 6 ), benzylidenemalonate, and 1,2‐bis(chloromethyl)benzene gave 7 , 19 and 20 , respectively. Reaction of 5 with suitable electrophiles (Mannich bases of arylalkanone), 1,4‐dichlorobenzene (diarylmethylation), and formylation afforded 8 / 9 , 21 / 22 , and 23 , respectively. J. Heterocyclic Chem., (2011).