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Coumarins: Facile and Expeditious Synthesis via Keggin‐Type Heteropolycompounds under Solvent‐Free Condition
Author(s) -
Rafiee Ezzat,
Fakhri Akram,
Joshaghani Mohammad
Publication year - 2013
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.621
Subject(s) - chemistry , catalysis , phenols , molar ratio , reaction conditions , solvent , organic chemistry , combinatorial chemistry
Different Keggin‐type heteropolycompounds were used in Pechmann reaction to obtain biologically active coumarins. Effect of solvent, catalyst loading, and molar ratios of substrates was studied to introduce the best reaction condition. The optimized reaction condition was extended to Pechmann reaction of methylacetoacetate with various monohydric and polyhydric phenols. This rapid procedure afforded structurally diverse coumarins with high to excellent yields. Short reaction times, simple work‐up, and mild reaction conditions were advantages of this method. The optimized catalysts were reusable for four runs.