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Synthesis of substituted N ‐[4(5‐methyl/phenyl‐1,3,4‐oxadiazol‐2‐yl)‐3,6‐dihydropyridin‐1(2 H )‐yl]benzamide/benzene sulfonamides as anti‐inflammatory and anti‐cancer agents
Author(s) -
Gangapuram Madhavi,
Redda Kinfe K.
Publication year - 2009
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.62
Subject(s) - chemistry , benzamide , benzene , sodium borohydride , medicinal chemistry , ethanol , organic chemistry , catalysis
Fourteen novel substituted N ‐[4(5‐methyl/phenyl‐1,3,4‐oxadiazol‐2‐yl)‐3,6‐dihydropyridin‐1(2 H )‐yl] benzamide/benzene sulfonamides ( 11a , 11b , 11c , 11d , 11e , 11f , 11g , 11h , 11i , 11j , 11k , 11l , 11m , 11n ) were synthesized in fair to good yields via sodium borohydride reduction of the corresponding substituted N ‐(benzoylimino)‐4‐(5‐methyl/5‐phenyl‐1,3,4‐oxadiazol‐2yl) pyridinium ylide 10a , 10b , 10c , 10d , 10e , 10f , 10g , 10h , 10i , 10j , 10k , 10m , 10n in absolute ethanol. J. Heterocyclic Chem., (2009)