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In vitro cytotoxic evaluation of some new heterocyclic sulfonamide derivatives
Author(s) -
Ghorab Mostafa M.,
AlSaid Mansour S.,
ElHossary Ebaa M.
Publication year - 2011
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.619
Subject(s) - chemistry , sulfonamide , quinoline , carbonic anhydrase , moiety , in vitro , ehrlich ascites carcinoma , acetazolamide , in vivo , doxorubicin , stereochemistry , combinatorial chemistry , enzyme , biochemistry , organic chemistry , chemotherapy , medicine , microbiology and biotechnology , surgery , anesthesia , biology
Sulfonamide‐bearing compounds posses many types of biological activities and have been recently reported to show substantial antitumor activity in vitro and/or in vivo . There are a variety of mechanisms for the anticancer activity, and the most prominent mechanism is the inhibition of carbonic anhydrase isozymes. This work reports the synthesis of some new quinoline, pyrimido[4,5‐ b ]quinoline and 3,1‐oxazinoquinoline derivatives bearing a sulfonamide moiety. All the newly synthesized compounds were evaluated for their in vitro anticancer activity against Ehrlich ascites carcinoma cells. Compounds 10 , 13 , and 26 were the most active compounds with IC 50 values of 6.1 μ M , 6.8 μ M , and 6.4 μ M , respectively, and exhibited better activities than the reference drug doxorubicin (IC 50 = 68.1 μ M ). J. Heterocyclic Chem., 2011.