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Microwave‐mediated synthesis and antibacterial activity of some novel 2‐(substituted biphenyl) benzimidazoles via Suzuki‐Miyaura cross coupling reaction and their N ‐substituted derivatives
Author(s) -
Raut Changdev Namdev,
Bharambe Shailendra Mitharam,
Pawar Yogesh Ashok,
Mahulikar Pramod Pandurang
Publication year - 2011
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.610
Subject(s) - benzimidazole , chemistry , biphenyl , antibacterial activity , combinatorial chemistry , coupling reaction , microwave irradiation , suzuki reaction , microwave , stereochemistry , organic chemistry , medicinal chemistry , bacteria , catalysis , palladium , genetics , biology , physics , quantum mechanics
A series of some novel 2‐(substituted biphenyl) benzimidazoles and their N ‐substituted derivatives were synthesized via microwave‐mediated Suzuki‐Miyaura coupling of 2‐(4‐iodophenyl)‐1 H ‐benzimidazole or 2‐(4‐iodophenyl)‐6‐amino‐1 H ‐benzimidazole and arylboronic acids. The method reported herein offers advantageous shorter reaction times, higher yields and is applicable to a large set of substrates. All the synthesized compounds were screened for their antibacterial activity against Staphylococcus aureus and Salmonella typhimurium bacterial species. J. Heterocyclic Chem., (2011).