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One‐step synthesis of 2,4,5‐trisubstituted pyrimidines
Author(s) -
Zhang ChuangJun,
Han WenYong,
Gao MiXiang,
Xu FeiFei,
Zhang ZunTing
Publication year - 2011
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.606
Subject(s) - chemistry , thiourea , guanidine , combinatorial chemistry , isoflavones , two step , drug discovery , elemental analysis , organic chemistry , biochemistry
A simple and straightforward methodology towards the synthesis of 2,4,5‐trisubstituted pyrimidines has been developed by one‐step reaction of isoflavones with thiourea or guanidine. Ten 2‐mercapto‐4,5‐diphenylpyrimidines and eight 2‐amino‐4,5‐diphenylpyrimidines were reported. All of them were characterized by FT‐IR, NMR, and elemental analysis. A variety of substrates can participate in the process with good yields and high purities, making this methodology suitable for library synthesis in drug discovery. J. Heterocyclic Chem., (2011).