Premium
Synthesis of spiro thiazolo[3,2‐ a ]pyrimidine compounds by one‐pot sequential 1,3‐dipolar cycloadditions
Author(s) -
Li Xiaofang,
Zheng Aiting,
Liu Bin,
Li Guobin,
Yu Xianyong,
Yi Pinggui
Publication year - 2011
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.578
Subject(s) - chemistry , sarcosine , azomethine ylide , isatin , pyrimidine , cycloaddition , nitrile , 1,3 dipolar cycloaddition , elemental analysis , proton nmr , medicinal chemistry , carbon 13 nmr , organic chemistry , stereochemistry , catalysis , glycine , biochemistry , amino acid
Abstract A new class of spiro thiazolo[3,2‐ a ]pyrimidine compounds were synthesized by the one‐pot sequential 1,3‐dipolar cycloaddition of azomethine ylide (generated from isatin and sarcosine)–nitrile oxide to 2‐arylmethylidene‐6,7‐dihydro‐5 H ‐thiazolo[3,2‐ a ]pyrimidin‐3‐ones in moderate yields. The structures of all the products were characterized thoroughly by NMR, MS, IR, elemental analysis, and NMR together with X‐ray crystallographic analysis. J. Heterocyclic Chem., (2011).