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An efficient one‐pot synthesis of pyrazolo[3,4‐ b ]pyridinone derivatives catalyzed by L ‐proline
Author(s) -
Shi ChunLing,
Chen Hui,
Shi DaQing
Publication year - 2011
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.573
Subject(s) - chemistry , proline , aldehyde , catalysis , pyridine , amine gas treating , organic chemistry , medicinal chemistry , combinatorial chemistry , amino acid , biochemistry
A series of 3‐methyl‐1,4‐disubstituted‐4,5‐dihydro‐1 H ‐pyrazolo[3,4‐ b ]pyridine‐6(7 H )‐ones was synthesized via the three‐component reaction of aldehyde, 3‐methyl‐1‐phenyl‐1 H ‐pyrazol‐5‐amine, and Meldrum's acid catalyzed by L ‐proline. This protocol has the advantages of easier work‐up, milder reaction conditions, and high yields. J. Heterocyclic Chem., (2011).