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An efficient and clean Michael addition of indoles to electron‐deficient olefins under solvent‐ and catalyst‐free condition
Author(s) -
Liu XiongLi,
Xue Dong,
Zhang ZunTing
Publication year - 2011
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.569
Subject(s) - chemistry , indole test , michael reaction , catalysis , solvent , organic chemistry , combinatorial chemistry
An efficient Michael addition of indoles to electron‐deficient olefins under solvent‐ and catalyst‐free condition afforded biologically important 3‐substituted indole derivatives in good to excellent yields was reported. The acidic NH proton of indole plays a key role in Michael addition of indoles to electron‐deficient olefins. This very simple procedure provides an efficient and clean process for the synthesis of indole derivatives. J. Heterocyclic Chem., (2011).

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