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Synthesis and cytotoxicity of nitrogen mustard/tripolypyrrole conjugate
Author(s) -
Liu CunJiang,
Liu YanHong,
Cao LiFeng,
Ye Yong,
Zhao YuFen
Publication year - 2008
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570450647
Subject(s) - chemistry , conjugate , nitrogen mustard , chloroform , nitrogen , cytotoxicity , linker , coupling reaction , stereochemistry , organic chemistry , combinatorial chemistry , biochemistry , in vitro , catalysis , medicine , mathematical analysis , mathematics , surgery , chemotherapy , computer science , operating system , cyclophosphamide
A series of nitrogen mustard derivatives were synthesized by chloroform reaction and coupling reaction using DCC/ HOBT as promoting additives. The structure of compound was confirmed by 1 H NMR, 31 P NMR, MS and IR. The data show that the nitrogen mustard with tripolypyrrole as the linker inhibits all the four tested cells and has the highest activity.