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A new convenient synthesis of 2,4‐disubstituted‐1,2,4‐triazolo[1,5‐ a ] quinazolin‐5(4 H )‐ones
Author(s) -
Shawali Ahmad S.,
Hassaneen Hamdi M.,
Shurrab Nabil Kh.
Publication year - 2008
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570450642
Subject(s) - chemistry , combinatorial chemistry , stereochemistry , d 1 , medicinal chemistry , computational chemistry , biochemistry , receptor
A novel series of 2,4‐disubstituted‐1,2,4‐triazolo[1,5‐ a ]quinazolin‐5(4 H )‐ones were prepared by Dimroth rearrangement of their respective isomers namely 1,4‐disubstituted‐[1,2,4]triazolo[4,3‐ a ]‐quinazolin‐5(4 H )‐ones. The latter were prepared via new synthetic strategy based on 1,5‐elecrocyclization of the respective N ‐(4‐oxo‐3‐phenylquinazolin‐2‐yl)nitrilimines.

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