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Enantioselective 1,3‐dipolar cycloaddition reactions using chiral lanthanide catalysts
Author(s) -
Gołȩbiewski W. Marek,
Gucma Mirosław
Publication year - 2008
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570450620
Subject(s) - chemistry , enantioselective synthesis , cycloaddition , nitrile , lanthanide , 1,3 dipolar cycloaddition , catalysis , stereoselectivity , aryl , organic chemistry , ion , alkyl
Regio‐ and stereoselective 1,3‐dipolar cycloaddition of nitrile oxides to internal 2‐pentenols, α,β‐unsaturated esters and amides catalyzed by R ‐(+) BINOL‐lanthanide complexes affords corresponding 3‐aryl‐2‐isoxazolines with enantioselectivities up to 89% ee.