Premium
A facile one pot synthesis of 2, 4‐diamino‐6‐substituted s‐triazine derivatives
Author(s) -
Sathunuru Ramadas,
Melendez Victor,
Kozar Michael P.,
Lin Ai J.
Publication year - 2008
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570450618
Subject(s) - chemistry , triazine , pyridine , scope (computer science) , chloride , combinatorial chemistry , organic chemistry , programming language , computer science
A novel and facile one‐pot procedure for the preparation of 2,4‐diamino‐6‐substituted‐s‐triazine derivatives (IIa‐n) was reported. The scope of its application was demonstrated with a number of examples. The new procedure involved treatment of proguanil or chloroproguanil with acyl chloride or alky chlorooxoacetate in pyridine at ice cold temperature followed by reflux overnight to give good yields of the desired products.