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Synthesis and reactions of 3‐pyrrolidinones
Author(s) -
Amer Fathy AbdelKader,
Hammouda Metwally,
AbdelWahab Bakr Fathy,
ElAhl AbdelAziz Sayed
Publication year - 2008
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570450602
Subject(s) - pyrrolidinones , chemistry , pyrrolidine , ring (chemistry) , reactivity (psychology) , alkyl , methylene , organic chemistry , medicine , alternative medicine , pathology
This review presents a survey of the synthetic methods and reactions of 3‐pyrrolidinones I (R = H, alkyl, acyl, ester; R 1 = H, alkyl, cyano, ester, etc). 3‐Pyrrolidinones are synthetically versatiles substrate, as they can be used for synthesis of a large variety of heterocyclic compounds, such as indoles and 5‐deazapteroic acid analogues and as a raw material for drug synthesis. The high reactivity of an active methylene group next to the carbonyl of the pyrrolidine ring is useful for various syntheses.