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Synthesis and crystal structure of 5‐pyrazol‐4,5‐dihydropyrazoles derivatives
Author(s) -
Xie Zhengfeng,
Mo Xuexia,
Liu Gang,
Liu Fangming
Publication year - 2008
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570450539
Subject(s) - chemistry , triclinic crystal system , monoclinic crystal system , acetic acid , crystal structure , crystallography , aryl , single crystal , aldehyde , stereochemistry , proton nmr , medicinal chemistry , organic chemistry , catalysis , alkyl
A series of 1‐acetyl(or phenyl)‐3‐aryl‐5‐(1‐phenyl‐3‐methyl‐5‐aryloxyl‐pyrazol)‐4,5‐dihydropyrazole derivatives have been efficiently synthesized under refluxing in glacial acetic acid with two kinds of hydrazines and five kinds of chalcones of 1‐phenyl‐methyl‐5‐phenoxyl‐pyrazol‐4‐aldehyde. The structures were confirmed on the basis of 1 H NMR, IR, MS and element analysis, and the crystal structure of the compound 4c was determined by single crystal X‐ray diffraction. The compound 4c belongs to monoclinic system with space group P2(1)/n, a = 11.8779(3) nm, b = 12.0901(2) nm, c = 17.7004(4) nm, α = 90°, β = 100.05(10)°, γ = 90°, Formula weight: 549.46, Triclinic V = 2502.89(9) nm 3 , D c = 1.458 Mg/m 3 , Z = 4, F (000) = 1128.