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A new route to pyrimido[1,6‐ a ]benzimidazole derivatives
Author(s) -
Bakavoli M.,
Rahimizadeh M.,
Ebrahimi A. R.,
Taghizadeh A.,
Davoodnia A.,
Nikpour M.
Publication year - 2008
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570450534
Subject(s) - chemistry , benzimidazole , bromine , chloroform , aryl , organic chemistry , combinatorial chemistry , medicinal chemistry , alkyl
AbstractCyclocondensation of orthophenylendiamines with 3‐bromopropionic acid in PPA afforded 2‐vinylbenzimidazoles which were subsequently converted to their corresponding 2‐(1,2‐dibromoethyl)‐1 H ‐benzimidazoles on treatment with bromine. Reaction of these compounds with aryl nitriles or aryl isocyanates in basic chloroform yielded 1‐arylpyrimido[1,6‐ a ]benzimidazoles and 2‐arylpyrimido[1,6‐ a ]‐benzimidazol‐3‐ones respectively.