A new route to pyrimido[1,6‐ a ]benzimidazole derivatives | Zendy

Bakavoli M. | Zendy; Rahimizadeh M. | Zendy; Ebrahimi A. R. | Zendy; Taghizadeh A. | Zendy; Davoodnia A. | Zendy; Nikpour M. | Zendy

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A new route to pyrimido[1,6‐ a ]benzimidazole derivatives

Author(s) -

Bakavoli M.,

Rahimizadeh M.,

Ebrahimi A. R.,

Taghizadeh A.,

Davoodnia A.,

Nikpour M.

Publication year - 2008

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570450534

Subject(s) - chemistry , benzimidazole , bromine , chloroform , aryl , organic chemistry , combinatorial chemistry , medicinal chemistry , alkyl

Cyclocondensation of orthophenylendiamines with 3‐bromopropionic acid in PPA afforded 2‐vinylbenzimidazoles which were subsequently converted to their corresponding 2‐(1,2‐dibromoethyl)‐1 H ‐benzimidazoles on treatment with bromine. Reaction of these compounds with aryl nitriles or aryl isocyanates in basic chloroform yielded 1‐arylpyrimido[1,6‐ a ]benzimidazoles and 2‐arylpyrimido[1,6‐ a ]‐benzimidazol‐3‐ones respectively.

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