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Phenacyl esters of acetic acid derivatives and their application for the synthesis of 2‐oxo‐4‐phenyl‐5‐(phenylhydrazono)‐2,5‐dihydro‐furan‐3‐derivatives
Author(s) -
Hlaváč Jan,
Hradil Pavel,
Mělnický Radek,
Kvapil Lubomír,
Šlézar Petr,
Grepl—— Martin,
Hradil Pavel,
Lyčka Antonín,
Grepl Martin
Publication year - 2008
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570450529
Subject(s) - chemistry , phenacyl , furan , acetic acid , organic chemistry , proton nmr , phenacyl bromide , medicinal chemistry
Coupling of various substituted phenacyl acetates 1 and diazonium salts 3 was studied. If the phenacyl acetates were substituted by an electronaceptor group such as CN or COOEt 3‐substituted phenyl‐5‐(phenyl‐hydrazono)‐5 H ‐furan‐2‐ones 4 were formed. Also synthesis of aza and diaza analogs is described. The compounds were characterized using MS and NMR spectroscopy.