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Palladium‐catalyzed cyclization of 3‐bromopyridine‐4‐carbaldehyde with carbon monoxide and carboxylic acids
Author(s) -
Cho Chan Sik,
Uk Kim Jun
Publication year - 2008
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570450523
Subject(s) - chemistry , palladium , carbon monoxide , catalysis , pyridine , acetonitrile , base (topology) , palladium catalyst , carboxylic acid , organic chemistry , medicinal chemistry , mathematical analysis , mathematics
3‐Bromopyridine‐4‐carbaldehyde is cyclized with carboxylic acids in acetonitrile at 100° under carbon monoxide pressure in the presence of a catalytic amount of a palladium catalyst along with a base to afford the corresponding 3‐oxo‐1,3‐dihydrofuro[3,4‐ c ]pyridine‐1‐yl alkanoates in moderate to good yields.