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Synthesis and bio‐activity of novel iminophosphoranes
Author(s) -
Mohan Ch.,
Babu B. Hari,
Raju C. Naga,
Reddy C. Suresh,
Reddy V. Janardhan
Publication year - 2008
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570450514
Subject(s) - chemistry , alkyl , elemental analysis , antibacterial activity , atmosphere (unit) , mass spectrum , proton nmr , organic chemistry , medicinal chemistry , bacteria , ion , meteorology , genetics , physics , biology
The title compounds ( 5a‐j ) were synthesized by a two step process. 4‐Chlorophenyl and bis(2‐chloroethyl) amino‐dibromophosphites ( 1a and 1b ) were reacted with 1,8‐diaminonaphthalene ( 2 ) to form the diazaphosphinines ( 3a and 3b ). They were further reacted with different alkyl azides ( 4a‐e ) in THF at 50‐55 °C under N 2 atmosphere to afford the corresponding iminophosphoranes ( 5a‐j ). Their structures were established by elemental analysis, IR, 1 H, 13 C, 31 P NMR and Mass spectral data. All of them exhibited moderate antibacterial activity.