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The stereoselective synthesis of e ‐1,2‐bis(3‐indolizinyl)ethylenes by the reactions of 3‐thioformylindolizines with n ‐tributylphosphine
Author(s) -
Liu Weiwei,
Zhao Yueqiang,
Tu Shujiang,
He Ting,
Hu Hongwen
Publication year - 2008
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570450509
Subject(s) - chemistry , tributylphosphine , stereoselectivity , yield (engineering) , methylene , carbene , coupling reaction , ethylene , medicinal chemistry , organic chemistry , catalysis , materials science , metallurgy
3‐Thioformylindolizines undergo novel reductive coupling reaction in the presence of tributylphosphine to give E ‐1,2‐bis(3‐indolizinyl)ethylenes in high yield. These reactions proceed via (3‐indolizinyl)methylene carbene intermediate and provide a new, stereoselective synthesis of the bis(3‐indolizinyl)ethylene derivatives highly.