The stereoselective synthesis of  e ‐1,2‐bis(3‐indolizinyl)ethylenes by the reactions of 3‐thioformylindolizines with  n ‐tributylphosphine | Zendy

Liu Weiwei | Zendy; Zhao Yueqiang | Zendy; Tu Shujiang | Zendy; He Ting | Zendy; Hu Hongwen | Zendy

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The stereoselective synthesis of e ‐1,2‐bis(3‐indolizinyl)ethylenes by the reactions of 3‐thioformylindolizines with n ‐tributylphosphine

Author(s) -

Liu Weiwei,

Zhao Yueqiang,

Tu Shujiang,

He Ting,

Hu Hongwen

Publication year - 2008

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570450509

Subject(s) - chemistry , tributylphosphine , stereoselectivity , yield (engineering) , methylene , carbene , coupling reaction , ethylene , medicinal chemistry , organic chemistry , catalysis , materials science , metallurgy

3‐Thioformylindolizines undergo novel reductive coupling reaction in the presence of tributylphosphine to give E ‐1,2‐bis(3‐indolizinyl)ethylenes in high yield. These reactions proceed via (3‐indolizinyl)methylene carbene intermediate and provide a new, stereoselective synthesis of the bis(3‐indolizinyl)ethylene derivatives highly.

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